Lipoprotein Fractions and Antithrombin III Consumption During Clotting

Author:

Winter J H1,Bennett B1,McTaggart F2,Douglas A S1

Affiliation:

1. The Department of Medicine, University of Aberdeen, Scotland, U.K.

2. The Imperial Chemical Industries Limited, Pharmaceuticals Division Alderley Park, Cheshire, U.K.

Abstract

SummaryPlasma and serum antithrombin levels were measured in functional (initial rate measurement) and immunological assays together with serum lipid levels in normal subjects and patients with coronary artery disease. Specific antithrombin activity in plasma showed a negative correlation with triglyceride levels. The consumption of antithrombin activity during blood clotting was negatively correlated with both serum total triglyceride and heparin precipitable lipoprotein and positively correlated with serum high density lipoprotein cholesterol. Different blood lipoprotein fractions may influence the activity of the antithrombin III molecule.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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