Author:
Edson J. R,White J. G,Krivit W
Abstract
SummaryA case of very severe P. T. A. deficiency without hemorrhagic symptoms is described, and the possibility that the absence of a bleeding diathesis may have an explanation in the presently unknown interrelationship between 3 “contact phase” coagulation factors is suggested. The existence of “Fletcher factor” deficiency as an entity distinct from factor XI and XII deficiency is confirmed. The problems in establishing a diagnosis of P. T. A. deficiency are discussed. The authors believe that assay using known congenitally deficient plasma is the only certain method of diagnosing P. T. A. deficiency. The 3 members of the propositus’s family have minor P. T. A. deficiency, and the mode of inheritance in this family is consistent with the hypothesis of Rapaport et al.
Funder
Minnesota Chapter of the National Hemophilia Foundation, the Minnesota Heart Association, the Graduate School of the University of Minnesota, the American Cancer Society, the Public Health Service
National Cancer Institute
Public Health Service Research
Cited by
29 articles.
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