The Accumulation of Chromium Complexes in Skeletal Tissue

Abstract

SummaryStudies of the in vivo distribution of 51Cr-alloxantin complex show a high uptake by bone. 24 hours after intravenous injection, approximately 20% of the complex remains in the body, and 50—65% of this chromium is in skeleton. In vitro studies of its interaction with calcium carbonate and phosphate indicate a minimum of cation exchange, and therefore it is postulated that most of the interaction is due to a complex formation with the crystal lattice.