Effect of Local Urokinase on Arterial Occlusion of Lower Limbs-Reference-Cited by-同舟云学术

Effect of Local Urokinase on Arterial Occlusion of Lower Limbs

Published:1981 Issue:03 Volume:45 Page:230-232
ISSN:0340-6245
Container-title:Thrombosis and Haemostasis
language:en
Short-container-title:Thromb Haemost

Author:

Fiessinger J-N¹,Aiach M²,Capron L¹,Devanlay M²,Vayssairat M¹,Juillet Y¹

Affiliation:

1. The Chaire de Clinique Médicale et de Pathologie Vasculaire (Pr. E. Housset), Paris, France

2. et Département d'Hémostase, Laboratoire de Biochimie (Pr. M. Leclerc) Hôpital Broussais, Paris, France

Abstract

SummarySixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 patients showed that local arterial plasminemia occurred in only 1 patient. Local urokinase does not strongly stimulate “endogenous” thrombolysis and enhances “exogenous” thrombolysis only very inconstantly. A better adaptation of urokinase dosage or the use of an agent with a higher affinity for fibrin might improve the efficiency of local thrombolytic therapy.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1650176.pdf

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1. Plasma fibrinogen level as a potential predictor of hemorrhagic complications after catheter-directed thrombolysis for peripheral arterial occlusions;Journal of Vascular Surgery;2017-05

2. Thrombolyse des artériopathies des membres;EMC - Cardiologie-Angéiologie;2005-08

3. Thrombolysis in the Management of Lower Limb Peripheral Arterial Occlusion—A Consensus Document;Journal of Vascular and Interventional Radiology;2003-09

4. Thrombolysis in the Management of Lower Limb Peripheral Arterial Occlusion—A Consensus Document fn1fn1This study was supported in part by Abbott Laboratories, Abbott Park, Illinois; Behringweike AG, Marburg, Germany; Boehringer Ingelheim UK, Bracknell, Berkshire, United Kingdom; Boehringer Mannheim AG, Mannheim, Germany; Genentech, Inc., South San Francisco, California; and Knoll AG, Ludwigshafen, Germany. This study was endorsed by the Cardiovascular and Interventional Radiological Society of Europe, Brussels, Belgium; the European Society for Vascular Surgery, Milan, Italy; the Internal Society for Thrombosis and Hemostasis, Chapel Hill, North Carolina; the International Union of Angiology, Lisbon, Portugal; and the Society of Cardiovascular and Interventional Radiology, Fairfax, Virginia.aaDisclaimer: This Consensus Document deals with the use of thrombolytic therapy in the management of lower limb ischemia. Much of the discussion centers on published data. However, it is recognized that in clinical practice each case must be considered on its own merits, and that there may be good clinical reasons for adopting a different approach from those included in these guidelines. Participating societies and individuals wish to emphasize that the comments and recommendations in this Document should be taken as a whole and do not necessarily represent the only correct approach to the treatment of individual patients.;The American Journal of Cardiology;1998-01

5. Thrombolysis in acute lower limb ischaemia;European Journal of Vascular Surgery;1993-11