Inhibition of Platelet Function by Antiarrhythmic Drugs, Verapamil and Disopyramide

Author:

Han P1,Boatwright C2,Ardlie N G2

Affiliation:

1. The School of Applied Science, Canberra College of Advanced Education, Canberra, ACT., Australia

2. The Department of Medicine and Clinical Science, The John Curtin School of Medical Research, The Australian National University, Australia

Abstract

SummaryVarious cardiovascular drugs such as nitrates and propranolol, used in the treatment of coronary artery disease have been shown to have an antiplatelet effect. We have studied the in vitro effects of two antiarrhythmic drugs, verapamil and disopyramide, and have shown their inhibitory effect on platelet function. Verapamil, a calcium channel blocker, inhibited the second phase of platelet aggregation induced by adenosine diphosphate (ADP) and inhibited aggregation induced by collagen. Disopyramide similarly inhibited the second phase of platelet aggregation caused by ADP and aggregation induced by collagen. Either drug in synergism with propranolol inhibited ADP or collagen-induced platelet aggregation. Disopyramide at high concentrations inhibited arachidonic add whereas verapamil was without effect. Verapamil, but not disopyramide, inhibited aggregation induced by the ionophore A23187.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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