The Value of Phenformin and Ethyloestrenol in the Prevention of Deep Venous Thrombosis in Patients Undergoing Surgery

Abstract

SummaryThe effect of phenformin and ethyloestrenol on the incidence of post-operative deep venous thrombosis was studied in 314 surgical patients in a double-blind randomised trial.Although the laboratory tests suggested that the regime produced an increase in activators of the fibrinolytic system, the drugs used did not lower the incidence of post-operative deep venous thrombosis.Possible explanations of this paradox are advanced.