A Comparison of the Effect of Platelets and Erythrocytes on the Inhibitory Action of Blood Coagulation by Polybrene and Heparin

Author:

Shanberge J. N,Furuta S

Abstract

SummaryAlthough the inhibitory action of Polybrene and heparin on blood coagulation in vitro is inversely proportional to the number of platelets present, the reason for this in each case is different. Whereas heparin is counteracted by a substance present in platelets, the platelet factor 4, Polybrene is partially neutralized by adsorption onto the surface of the platelets.Under similar conditions Polybrene is adsorbed by erythrocytes while heparin is not.Platelet factor 4 not only is not anti-Polybrene but, like Polybrene, is also inhibitory in the intermediate product I formation test so that the two together have a greater inhibitory action than either one alone.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Influence of Platelet Factor 4 on the Neutralization of Heparin by Protamine;Annals of the New York Academy of Sciences;1989-06

2. Chemistry and Pharmacology of Heparin;Journal of Pharmaceutical Sciences;1973-04

3. 3 The Pharmacology of Heparin and Heparinoids;Progress in Medicinal Chemistry;1967

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