Hemostasis Abnormalities in Patients with Vascular Dementia and Alzheimer’s Disease

Author:

Mari D1,Parnetti L1,Coppola R1,Bottasso B1,Reboldi G P1,Senin U1,Mannucci P M1

Affiliation:

1. The Geriatrics Unit, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milan; and Gerontology and Geriatrics, University of Perugia, Italy

Abstract

SummarySince it has not been established to what extent abnormalities of hemostasis contribute to the occurrence and development of dementia, selected measurements of coagulation and fibrinolysis were obtained in elderly patients with Alzheimer’s disease (n = 22) or vascular dementia (n = 29), compared with healthy individuals in the same age range (n = 61). Hemostasis abnormalities were more frequent and marked in vascular dementia, being expressed as significant increases of plasminogen activator inhibitor type 1, von Willebrand factor, D-dimer. and activated factor VII. However, some hemostasis measurements (von Willebrand factor, activated factor VII) were abnormally high also in the patients with Alzheimer’s disease, a condition in which vascular damage is not considered to play a major pathogenetic role. It could not be established in this study whether or not these hemostatic abnormalities play a causal role in the pathogenesis of dementia, or whether they are secondary to inflammation and chronic vascular disease. Nevertheless, their presence may contribute to aggravating vascular disease.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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