Alterations in Vascular Endothelial Cell-related Plasma Proteins In Thalassaemic Patients and their Correlation with Clinical Symptoms-Reference-Cited by-同舟云学术

Alterations in Vascular Endothelial Cell-related Plasma Proteins In Thalassaemic Patients and their Correlation with Clinical Symptoms

Published:1995 Issue:04 Volume:74 Page:1045-1049
ISSN:0340-6245
Container-title:Thrombosis and Haemostasis
language:en
Short-container-title:Thromb Haemost

Author:

Butthep P¹,Bunyaratvej A²,Funahara Y³,Kitaguchi H³,Fucharoen S⁴,Sato S⁵,Bhamarapravati N⁶

Affiliation:

1. The Blood Disease Research Unit, Sirikit Medical Centre, Bangkok, Japan

2. The Department of Pathology, Faculty of Medicine, Rhamathibodi Hospital, Bangkok, Japan

3. The First Department of Physiology, Kobe University School of Medicine, Kobe, Japan

4. The Thalassaemia Centre, Bangkok, Japan

5. The Department of Hygiene, Kobe University School of Medicine, Kobe, Japan

6. The Vaccine Centre, Salaya, Mahidol University, Thailand

Abstract

SummaryAn increased level of plasma thrombomodulin (TM) in α- and β- thalassaemia was demonstrated using an enzyme-linked immunosorbent assay (ELISA). Nonsplenectomized patients with β-thalassaemia/ haemoglobin E (BE) had higher levels of TM than splenectomized cases (BE-S). Patients with leg ulcers (BE-LU) were found to have the highest increase in TM level. Appearance of larger platelets in all types of thalassaemic blood was observed indicating an increase in the number of younger platelets. These data indicate that injury of vascular endothelial cells is present in thalassaemic patients.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1649879.pdf

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