A Human Pharmacological Study Comparing Conventional Heparin and a Low Molecular Weight Heparin Fragment-Reference-Cited by-同舟云学术

A Human Pharmacological Study Comparing Conventional Heparin and a Low Molecular Weight Heparin Fragment

Published:1985 Issue:02 Volume:53 Page:208-211
ISSN:0340-6245
Container-title:Thrombosis and Haemostasis
language:en
Short-container-title:Thromb Haemost

Author:

Bratt G¹,Törnebohm E¹,Lockner D¹,Bergströ G²

Affiliation:

1. The Thrombosis Unit, Section of Hematology, Department of Internal Medicine, Huddinge University Hospital, Huddinge, Sweden

2. Department of Clinical Chemistry, Huddinge University Hospital, Huddinge, Sweden

Abstract

SummaryThe pharmacokinetics of a heparin fragment of low molecular weight (LMWH) of 4000-5000 D and unfractioned standard heparin (UFH) have been studied after i. v. injections of different doses and infusions in 8 humans.The heparin activity was significantly higher and the effect on APTT lower after LMWH fragment as compared to UFH in the same doses.The half-life of heparin activity was about 1 hr for UFH and about 2 hr for LMWH. LMWH was found to be eliminated according to first order kinetics and there were no signs of dose dependency.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1661275.pdf

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