Protein C Level at Birth

Author:

Polack B1,Pouzol P1,Amiral J2,Kolodie L1

Affiliation:

1. The Laboratoire d’Hématologie, Center Hospitalier Régional et Universitaire, Grenoble, France

2. The Diagnostica Stago, Asnière, France

Abstract

SummaryThe protein C level was determined, on cord blood, for 30 healtly newborns by electro-immuno assay using a monospecific antiserum. For the newborns the mean level of protein C related antigen is about one third of normal adults’ mean level. There is a good correlation between Protein C related antigen and prothrombin related antigen. The low level of these vitamin-K-dependent proteins is probably a consequence of partial liver immaturity at birth. Using two-dimensional immuno-electrophoresis we were unable to detect subcarboxylated forms of protein C. However these abnormal forms could be seen in vitamin-K deficiencies of neonates.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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