Fibrinolytic Activity and Protein C in Preeclampsia

Author:

Aznar J1,Gilabert J2,Estellés A3,España F3

Affiliation:

1. The Department of Clinical Pathology, Hospital de la Seguridad Social “La Fe”, Valencia, Spain

2. The Department of Obstetrics and Gynecology, Hospital de la Seguridad Social “La Fe”, Valencia, Spain

3. The Research Center, Hospital de la Seguridad Social “La Fe”, Valencia, Spain

Abstract

SummaryVarious parameters of the fibrinolytic system and antigenic and functional protein C and its inhibitor were studied during normal pregnancy and in patients with preeclampsia.The fast acting tissue-type plasminogen activator inhibitor level was found to increase progressively during normal pregnancy. This increase was more evident in cases of severe preeclampsia (p<0.05). No variations were observed in protein C levels in normal pregnancies but a reduction in protein C level was noted in patients with severe preeclampsia (p<0.01). In preeclampsia, the protein C inhibitor level was higher than in normal pregnancy; it was also higher in normal pregnancy when compared to the control group.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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