Anticoagulant Properties of Three Mucopolysaccharides Used in Rheumatology

Author:

Bauer F1,Schulz P1,Reber G1,Bouvier C A1

Affiliation:

1. The Hemostasis Unit, Geneva University Hospital, and the University Medical Center, Geneva, Switzerland

Abstract

SummaryThree mucopolysaccharides (MPS) used in the treatment of degenerative joint disease were compared to heparin to establish their relative potencies on 3 coagulation tests, the aPTT, the antifactor X a activity and the dilute thrombin time. One of the compounds, Arteparon®, was one fourth as potent as heparin on the aPTT, but had little or no influence on the 2 other tests. Further in vitro studies suggested that Arteparon® acted at a higher level than factor Xa generation in the intrinsic amplification system and that its effect was independent of antithrombin III. In vivo administration of Arteparon® confirmed its anticoagulant properties, which raises the question of the clinical use of this MPS.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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1. Mucopolysaccharide Vascular Coating Relationship to Environmental Factors;Biological Effects and Physics of Solar and Galactic Cosmic Radiation;1993

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