International Collaborative Study on the Assay of Commercially Available High and Low Molecular Weight Urokinases-Reference-Cited by-同舟云学术

International Collaborative Study on the Assay of Commercially Available High and Low Molecular Weight Urokinases

Published:1981 Issue:01 Volume:45 Page:034-037
ISSN:0340-6245
Container-title:Thrombosis and Haemostasis
language:en
Short-container-title:Thromb Haemost

Author:

Gaffney P J¹,Tydeman S M¹,Kirkwood T B L¹,Aronson D²,Murano G²

Affiliation:

1. The National Institute for Biological Standards and Control, Holly Hill, Hampstead, London, U. K

2. The Bureau of Biologies, Department of Health, Education, and Welfare, Food and Drug Administration, Bethesda, Maryland, U.S.A

Abstract

SummaryUrokinases of different molecular weights are now commercially available. An international collaborative study (eight laboratories) has been conducted to investigate the effect of type and concentration of plasminogen on the assay of two different urokinase preparations against the International Reference Preparation (IRP). Considerable inter-laboratory variation in relative potency estimation was found, and a small effect of plasminogen concentration, independent of type, was apparent.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1650124.pdf

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1. Stabilized procedure for the determination of urokinase fibrinolytic potency;Analytical Biochemistry;1991-04

2. Urokinase: Stability Studies in Solution and Lyophilized Formulations;Drug Development and Industrial Pharmacy;1990-01

3. COMPARISON OF THROMBOLYTIC, FIBRINOLYTIC, AND FIBRINOGENOLYTIC PROPERTIES OF TISSUE PLASMINOGEN ACTIVATOR, STREPTOKINASE, SINGLE-CHAIN UROKINASE, HIGH MOLECULAR WEIGHT AND LOW MOLECULAR WEIGHT UROKINASE IN HUMAN PLASMAIN VITRO;Fundamental & Clinical Pharmacology;1988-11-12

4. Plasminogen Activators, Tissue Degradation, and Cancer;Advances in Cancer Research;1985

5. Comparative study of thrombolysis by high and low molecular weight urokinase in an in vitro perfusion system;Thrombosis Research;1983-09