HLA Antigens and Factor VIII Antibody in Classic Hemophilia-Reference-Cited by-同舟云学术

HLA Antigens and Factor VIII Antibody in Classic Hemophilia

Published:1981 Issue:04 Volume:46 Page:687-689
ISSN:0340-6245
Container-title:Thrombosis and Haemostasis
language:en
Short-container-title:Thromb Haemost

Author:

Frommel D¹,Allain J P²,Saint-Paul E³,Bosser C⁴,Noël B⁴,Mannucci P M⁵,Pannicucci F⁶,Blombäck M⁷,Prou-Wartelle O⁸,Muller J Y⁸

Affiliation:

1. The Participating Centers: I.N.S.E.R.M. U 56 & Clinique de Pédiatrie Université Paris-Sud, Bicêtre

2. Internats médico-pédagogiques pour Jeunes hémophiles de la Croix Rouge franҫaise, Centre Air & Soleil

3. Centre E. Rémigy

4. Centre I’Espoir, France

5. Ospedale Policlinico, Milano

6. Spedali Riuniti di San Chiara, Pisa, Italy

7. Karolinska Sjukhuset, Stockholm, Sweden

8. Tissue Typing Laboratories, Centre National de Transfusion Sanguine, Paris

Abstract

SummaryPossible interrelations between the immune response factor VIII and the major histocompatibility system were investigated in 57 multi-transfused hemophilic brothers belonging to 26 families. Linkage appears very unlikely although formal proof of independence cannot be offered. The HLA system, therefore, does not provide markers predictive for the development of antibodies to factor VIII in severe hemophilia A.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1653453.pdf

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