Affiliation:
1. Department of Geriatrics, Shandong First Medical University, Jinan,
China
2. Shandong Institute of Endocrine and Metabolic Diseases, Medical
University, Jinan, China
Abstract
AbstractDiabetes mellitus (DM) causes damage to major organs, including the heart, liver,
brain, kidneys, eyes, and blood vessels, threatening the health of the
individuals. Emerging evidence has demonstrated that lncRNAs has important
functions in the pathogenesis of human diseases, such as cancers,
neurodegenerative diseases, cardiac fibroblast phenotypes, hypertension, heart
failure, atherosclerosis and diabetes. Recently, H19, a lncRNA, has been
reported to shown to participate in the regulatory process of muscle
differentiation, glucose metabolism, and tumor metastasis, as well as
endometrial development. However, the roles of H19 in DM were still not
completely understood. This review was conducted to summarize the functions of
H19 in diabetes and discuss the challenges and possible strategies of H19 in
DM.
Funder
Development
Projects of Jinan City
Natural Science Foundation
of China
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism