Abstract
AbstractIridium-catalyzed C–H activation and borylation reactions operate under mild conditions that enable easy and atom-economical installation of the versatile boronate ester group in (het)arenes and alkanes. The standard catalytic system for iridium-catalyzed borylation uses [Ir(cod)(OMe)]2 as a precatalyst, a bipyridine type ligand, and B2pin2 or HBpin as the borylating agent. Initially, a bipyridine-ligated trisboryl–iridium complex is generated that enables the borylation reaction and the regioselectivity is mainly governed by the sterics of substituents present on the ring. As a result, monosubstituted and 1,2-disubstituted arenes give mixtures of isomers. Significant efforts by several research groups have overcome the selectivity issue for directed proximal C–H borylation by introducing a directing group and newly developed ligands. This short review aims to summarize recent elegant discoveries in directed C(sp2)–H and C(sp3)–H borylation by using heterobidentate ligand (P/N–Si, N–B, and N–C) coordinated iridium catalysts.1 Introduction2 Iridium-Catalyzed Directed C–H Borylation of C(sp2)–H Bonds3 Iridium-Catalyzed Directed C–H Borylation of C(sp3)–H Bonds4 Conclusions
Funder
Science and Engineering Research Board – Core Research Grant
Science and Engineering Research Board – Scientific and Useful Profound Research Advancement
Science and Engineering Research Board – Science and Technology Award for Research
University Grants Commission
Council of Scientific and Industrial Research
Subject
Organic Chemistry,Catalysis
Cited by
14 articles.
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