Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata-Reference-Cited by-同舟云学术

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Published:2019-01-16 Issue:06 Volume:85 Page:444-452
ISSN:0032-0943
Container-title:Planta Medica
language:en
Short-container-title:Planta Med

Author:

Zhang Bao-Jun¹²³,Fu Wen-Wei¹²,Wu Rong¹²,Yang Jin-Ling¹²,Yao Cai-Yun⁴,Yan Bing-Xiong⁴,Tan Hong-Sheng¹²,Zheng Chang-Wu¹²,Song Zhi-Jun⁴,Xu Hong-Xi¹²

Affiliation:

1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China

2. Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China

3. Department of Pharmacy, ShangHai PuTuo District People Hospital, Shanghai, Peopleʼs Republic of China

4. Guangxi Botanical Garden of Medicinal Plants, Nanning, Peopleʼs Republic of China

Abstract

Six new prenylated xanthones (1–6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15–17 showed moderate inhibitory effects on tumor cell growth, with IC50s ranging from 3.7 to 14.7 µM.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0828-9831.pdf

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