Affiliation:
1. Department of Pediatric
Intensive Care medicine, Second Hospital of Lanzhou University, Lanzhou, Gansu,
China
2. endocrinology, The First
People's Hospital of Chongqing Liangjiang New Area,
endocrinology
Abstract
Abstract
Background Probiotic supplements may benefit to reduce inflammation and
oxidative stress in patients with gestational diabetes, and this meta-analysis
aims to explore the impact of probiotic supplementation on inflammation and
oxidative stress for gestational diabetes.
Methods PubMed, EMbase, Web of science, EBSCO, and Cochrane library
databases were systematically searched, and we included randomized controlled
trials (RCTs) assessing the effect of a probiotic supplement on inflammation and
oxidative stress in patients with gestational diabetes.
Results Five RCTs were finally included in the meta-analysis. Overall,
compared with control intervention for gestational diabetes, probiotic
supplementation intervention showed significantly reduced CRP
(MD=−1.72; 95% CI=−2.54 to
−0.90; P<0.0001), IL-6 (MD=−0.42; 95%
CI=−0.66 to −0.18; P=0.0005) and MDA
(MD=−0.88; 95% CI=−1.10 to
−0.66; P<0.00001), increased NO (MD=2.42; 95%
CI=0.80 to 4.04; P=0.003) and TAC (SMD=0.86; 95%
CI=0.19 to 1.54; P=0.01), but showed no obvious impact on GSH
(MD=13.73; 95% CI=−35.84 to 63.31;
P=0.59).
Conclusions Probiotic supplementation is effective to alleviate
inflammation and oxidative stress for gestational diabetes.
Funder
Municipal Health Commission and Chongqing Science
and Technology Bureau Joint Medical Research Project
Subject
Maternity and Midwifery,Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献