Affiliation:
1. Graduate School of Pharmaceutical Sciences, Tokushima University
2. Department of Preventive Dentistry, Graduate School of Biomedical Sciences, Tokushima University
Abstract
AbstractA three-component coupling reaction of ortho-phthalaldehyde, 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide, and various primary amines readily afforded novel phosphorus-substituted stable isoindoles in good to excellent yields. The importance of the reversible ring-opening of 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide by methanolysis in the three-component coupling reaction became apparent.
Funder
Japan Society for the Promotion of Science
Subject
Organic Chemistry,Materials Science (miscellaneous),Biomaterials,Catalysis