Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

Abstract

AbstractBromamine-T (BAT) is a notable member of a special class of compounds called organic haloamines, which are oxidising agents. It can act as the source of halonium ions, hypohalite species, and N-anions, whilst also displaying basic and nucleophilic properties. Bromamine-T finds wide application as an efficient reagent for various organic transformations, such as aminobromination, amination, oxidation, and others. It can be used under mild conditions and has low toxicity. Moreover, due to its immense biological significance, this reagent is piquing the interest of many researchers.1 Introduction1.1 The Sodium Salt of N-Bromo-p-toluenesulfonamide (Bromamine-T or TsNBrNa): Reagent Overview1.2 Physical Properties of Bromamine-T1.3 Preparation and Characterisation of Bromamine-T2 Biological Significance of Bromamine-T3 Organic Transformations Using Bromamine-T3.1 Aminobromination3.2 Amination3.3 Aminohydroxylation3.4 Aziridination3.5 Bromination3.6 Oxidation: Kinetic and Mechanistic Studies4 Conclusion