Synthesis of Multisubstituted Guanidines through Palladium-Catalyzed Insertion of Isonitriles

Author:

Yang Li1,Tang Hai-Tao2,Li Pei-Xia2,Meng Xiu-Jin2,Pan Ying-Ming2

Affiliation:

1. Guangxi Key Laboratory of Special Non-wood Forest Cultivation and Utilization, Guangxi Zhuang Autonomous Region Forestry Research Institute

2. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University

Abstract

A new method for the synthesis of multisubstituted guanidines through tandem intermolecular insertion of isonitriles with un­activated amides has been developed. In this study, isonitriles could be used not only as reaction materials but also as the source of amines.

Funder

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

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