A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis-Reference-Cited by-同舟云学术

A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis

Published:2018-05-09 Issue:10 Volume:29 Page:1346-1350
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Carvalho Luísa¹^ORCID,Sequeira André¹,Lourenço Ana¹,Ferreira Luísa¹,Branco Paula¹,Mendes Zita²,Lourenço Nuno²,Figueiredo Margarida²

Affiliation:

1. LAQV, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa

2. Hovione FarmaCiencia SA, R&D, Campus do Lumiar

Abstract

An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.

Funder

Ministério da Educação e Ciência

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610127.pdf

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