Affiliation:
1. Organic Synthesis Laboratory, Fluoro-Agrochemicals Department, CSIR-Indian Institute of Chemical Technology
Abstract
The stereoselective total synthesis of Sch-725674 in 14 linear synthetic steps with 10.3% overall yield is described. The synthesis started from commercially available starting materials, d-ribose and (R)-benzyl glycidol. The key reactions involved CBS reduction, Julia–Kocienski olefination, Horner–Wadsworth–Emmons reaction, and Shiina macrolactonization.
Subject
Organic Chemistry,Materials Science (miscellaneous),Biomaterials,Catalysis
Cited by
5 articles.
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