Affiliation:
1. School of Chemistry and Chemical Engineering, Shandong University
2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University
Abstract
A novel oxidative amination of sp3 C–H bonds was developed for the efficient synthesis of imidazo[1,5-a]quinolines from readily available α-amino acids and (2-azaaryl)methanes. This domino protocol, which was established in a TBAI-TBHP oxidation system, includes transition-metal-free decarboxylation and intramolecular cyclization. This method represented a new avenue for the synthesis of N-heterocycles using 2-methylquinolines as the synthon of quinoline-2-carbaldehydes.
Funder
National Natural Science Foundation of China
State Key Laboratory of Natural and Biomimetic Drugs of Peking University
Subject
Organic Chemistry,Catalysis
Cited by
12 articles.
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