Affiliation:
1. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University
2. School of Chemical Engineering, Guizhou Minzu University
Abstract
A new strategy has been developed for the synthesis of 2,5-disubstituted oxazoles from easily available arylacetylenes and α-amino acids in the presence of Cu(NO3)2•3H2O and iodine. This reaction process involves the I2/Cu(NO3)2•3H2O-assisted transformation of arylacetylene to α-iodo acetophenone, Kornblum oxidation to phenylglyoxal, condensation to imine, decarboxylation/annulation/oxidation reaction sequence to approach 2,5-disubstituted oxazoles.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Hubei Province
Cited by
7 articles.
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