Affiliation:
1. Key Laboratory of Organic Synthesis of Jiangsu Province
Abstract
Treatment of olefinic amides with N-bromosuccinimide (NBS) in water is reported. Monobromobenzoxazines were mainly formed at room temperature, while at 80 °C multibromobenzoxazines were preferentially generated. Mechanism studies showed that the reaction might proceed via a cascade of electrophilic addition at the C=C bond followed by electrophilic substitution at the aromatic ring. No additives are required in this protocol.
Funder
National Natural Science Foundation of China
Subject
Organic Chemistry,Catalysis
Cited by
14 articles.
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