Affiliation:
1. Department of Organic and Biomolecular Chemistry, Ural Federal University
2. Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
3. InterBioScreen Ltd.
Abstract
A new synthetic protocol for nucleophilic substitution of hydrogen in quinoxalones and pteridinones by the action of 5,7-dihydroxycoumarins and related m-dihydroxybenzene compounds has been developed. The C–C coupling reaction proved to proceed smoothly under rather mild conditions, thus giving the corresponding C–H functionalized products in good yields. The advantages of this environmentally benign protocol are high regio- and chemoselectivity, and an easy workup procedure. Direct incorporation of the coumarin moiety into the pyrazine ring in pteridines or quinoxalines provides a short pathway to pyrazine-coumarin hybrid compounds.
Funder
Ministry of Education of the Russian Federation
Russian Science Foundation
Subject
Organic Chemistry,Catalysis
Cited by
13 articles.
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