Affiliation:
1. Division of Crop Protection Chemicals, CSIR – Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India
2. AcSIR – Indian Institute of Chemical Technology
Abstract
A simple, green protocol has been accomplished for the synthesis of dihydrospirofuro[2,3-c]pyrazoles in aqueous medium involving pyrazolone and aldehydes in a one-pot reaction promoted by bis(acetoxy)iodobenzene (BAIB) at ambient temperature. The protocol presented herein describes a new transformation where two molecules of pyrazolone react with an aldehyde in a Knoevenagel condensation followed by a Michael addition, and the resulting dienol was rearranged to the title compound. High compatibility, easy work-up, and excellent yields are the advantages of this protocol.
Cited by
12 articles.
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