An Aniline-Mediated Regioselective Synthesis of Quinoxalin-2-ones via the Condensation of α-Ketimine Esters with 2-Aminoanilines-Reference-Cited by-同舟云学术

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An Aniline-Mediated Regioselective Synthesis of Quinoxalin-2-ones via the Condensation of α-Ketimine Esters with 2-Aminoanilines

Published:2018-04-03 Issue:11 Volume:50 Page:2221-2230
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Huynh Huy¹,Çalimsiz Selçuk¹,Wangun Hilaire²,Rainey Trevor³,McGinitie Teague²,Liao Xiaoming⁴,Yu Lizhi⁴

Affiliation:

1. Department of Process Chemistry

2. Department of Analytical Chemistry

3. Department of Process Chemistry, Gilead Sciences

4. Department of Process Development and Manufacturing, Pharmaron Beijing, Co. Ltd.

Abstract

A highly regioselective method for the condensation of α-ketimine esters with 2-aminoanilines for the construction of quinoxalin-2-one derivatives is described. The substrate scope with 2-aminoaniline derivatives and different α-keto esters is explored with yields ranging from 44 to 90% and typical isolated regioselectivities between 6.4 to >25:1.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1609345.pdf

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quinoxalin‐2(1 H )‐ones: Chemical Synthesis, Fluorescence Properties and Applications;European Journal of Organic Chemistry;2022-12-22

2. Regioselective Synthesis of Quinoxalin-2-one Derivatives Regulated by Acid and Base;HETEROCYCLES;2020

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