Trichloroisocyanuric Acid Induced Chlorine Radical Cascade Chlorination/Carbocyclization of Acrylamides: Constructing Chlorinated Oxindoles by C–Cl and C–C Bond-Forming Reactions-Reference-Cited by-同舟云学术

Trichloroisocyanuric Acid Induced Chlorine Radical Cascade Chlorination/Carbocyclization of Acrylamides: Constructing Chlorinated Oxindoles by C–Cl and C–C Bond-Forming Reactions

Published:2019-03-14 Issue:11 Volume:51 Page:2331-2338
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Su Yingpeng¹^ORCID,Cao Lindan¹,Shi Ya¹,Feng Yawei¹,Xue Wenxuan¹,Cao Guiyan¹,Wang Ke-Hu¹,Huang Danfeng¹,Huo Congde¹,Hu Yulai¹²

Affiliation:

1. College of Chemistry and Chemical Engineering, Northwest Normal University

2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University

Abstract

A metal- and additive-free strategy for the synthesis of oxindoles has been achieved through a chlorine radical-induced cascade chlorination/carbocyclization of N-aryl acrylamides. Trichloroisocyanuric acid (TCCA) is used as both radical initiator and chlorine source. A wide range of substrates can be applied in this process to directly afford chlorinated oxindoles via C–Cl and C–C bond formation.

Funder

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610868.pdf

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