Affiliation:
1. College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science
Abstract
An efficient NHC-catalyzed amidation between esters and amines or hydrazines is described. This strategy was tolerant for a wide scope of substrates, affording a series of amides (or hydrazides) in good to excellent yields (60–96%) under simple conditions. The approach was also used to synthesize the pharmaceutically relevant antidepressant moclobemide in 85% yield.
Subject
Organic Chemistry,Catalysis
Cited by
7 articles.
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