Affiliation:
1. College of Chemistry and Materials Engineering, Wenzhou University
Abstract
The exploration of catalytic potential of natural amino acid salt in activation of 1,3-dicarbonyls was carried out, in which maleimides and 2-(2-oxoindolin-3-ylidene)malononitriles were found to be good electrophiles and afforded the desired products with excellent yield and moderate optical purity. Control experiments showed that the secondary amino group of barium (S)-prolinate is critical to the catalytic activity as well as enantiocontrol, thus revealed an enamine activation mechanism is possible in the present methodology.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Cited by
6 articles.
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