Copper-Catalyzed Decarboxylative N-Arylation of Indole-2-carboxylic Acids-Reference-Cited by-同舟云学术

Copper-Catalyzed Decarboxylative N-Arylation of Indole-2-carboxylic Acids

Published:2019-01-10 Issue:08 Volume:51 Page:1803-1808
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Zhang Yan¹,Hu Zhe-Yao¹,Li Xin-Chang¹,Guo Xun-Xiang¹²

Affiliation:

1. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University

2. Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University

Abstract

A novel decarboxylative N-arylation of indole-2-carboxylic acids with aryl halides is developed. The reaction proceeds efficiently in the presence of Cu2O as the catalyst to give the corresponding N-aryl indoles in high yields. This synthetic method shows good functional group tolerance and offers an alternative route to construct N-aryl indoles.

Funder

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1611946.pdf

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