Affiliation:
1. College of Chemistry and Molecular Engineering, Zhengzhou University
2. Collaborative Innovation Center of New Drug Research and Safety Evaluation
Abstract
The organobase-mediated diastereoselective spirocyclopropanation of barbiturate-based olefins with 2,4-disubstituted benzyl chlorides has been developed. The reactions were carried out efficiently to afford the desired spirobarbiturate-cyclopropanes in up to 95% yield with more than 20:1 dr in favor of anti-isomers. In order to extend synthetic utility of the spiro-products, a Lewis acid induced cyclopropane-ring-expansion isomerization was also demonstrated.
Funder
National Natural Science Foundation of China
Henan Department of Education
Subject
Organic Chemistry,Catalysis
Cited by
17 articles.
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