Metal-free Deamidative Ugi Access to Isoindolinones-Reference-Cited by-同舟云学术

Metal-free Deamidative Ugi Access to Isoindolinones

Published:2018-07-10 Issue:14 Volume:29 Page:1842-1846
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Hammal Lamouri¹,El Kaïm Laurent²^ORCID,Baaziz Samira²¹,Kerim Mansour²,Cordier Marie³

Affiliation:

1. Laboratoire de Chimie Organique Appliquée, Université des Sciences et de la Technologie Houari Boumediene (USTHB)

2. Laboratoire de Synthèse Organique, CNRS, Ecole Polytechnique, ENSTA ParisTech - UMR 7652, Université Paris-Saclay

3. Laboratoire de Chimie Moléculaire, CNRS, Ecole Polytechnique - UMR 9168, Université Paris-Saclay

Abstract

A two-step isoindolone synthesis has been achieved by using an Ugi/oxidative vicarious nucleophilic substitution sequence starting from 3-nitrobenzoic acid and aromatic aldehydes. Loss of the amido group was observed as well as a further oxidative process towards hydroxyisoindolone derivatives after prolonged stirring open to the atmosphere.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610189.pdf

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