Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions-Reference-Cited by-同舟云学术

Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

Published:2018-08-20 Issue:24 Volume:50 Page:4963-4981
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Pearson Stuart¹,Fillery Shaun¹,Goldberg Kristin¹,Demeritt Julie²,Eden Jonathan²,Finlayson Jonathan²,Patel Anil²

Affiliation:

1. Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca

2. Formerly of Oncology Innovative Medicines, AstraZeneca

Abstract

Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610223.pdf

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