Affiliation:
1. Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University
Abstract
Polysubstituted 2-aminothiazoles have been synthesized via a one-pot three-component reaction of α-nitro epoxides, potassium thiocyanate, and primary amines without the need for any additives. This reaction proceeds smoothly in a highly efficient and eco-friendly manner with good to excellent yields. A possible mechanism is also proposed.
Funder
Natural Science Foundation of Zhejiang Province
National Natural Science Foundation of China
Subject
Organic Chemistry,Catalysis
Cited by
11 articles.
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