Synthesis of 1,3-Diols by O-Nucleophile Additions to Activated Alkenes-Reference-Cited by-同舟云学术

Synthesis of 1,3-Diols by O-Nucleophile Additions to Activated Alkenes

Published:2018-08-30 Issue:20 Volume:50 Page:3997-4007
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Gamba-Sánchez Diego¹,Prunet Joëlle²

Affiliation:

1. Laboratory of Organic Synthesis, Bio and Organocatalysis, Chemistry Department, Universidad de los Andes

2. WestCHEM, School of Chemistry, University of Glasgow

Abstract

The diastereoselective synthesis of 1,3-diols by addition of oxygen nucleophiles to activated alkenes is presented. This review focuses on homoallylic alcohol substrates that react with a relay compound to form an intermediate oxygen nucleophile, which in turn will lead to a protected 1,3-diol by intramolecular addition to the olefin moiety.1 Introduction2 Base Catalysis3 Organocatalysis4 Activation with Non-Metallic Electrophiles5 Activation with Transition Metal Derivatives6 Conclusions

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610248.pdf

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