Efficient S-Acylation of Thiourea-Reference-Cited by-同舟云学术

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Efficient S-Acylation of Thiourea

Published:2018-10 Issue:04 Volume:02 Page:0263-0267
ISSN:2509-9396
Container-title:SynOpen
language:en
Short-container-title:SynOpen

Author:

Jones David¹²³,Khandavilli Uday¹²^ORCID,O’Leary Eileen⁴,Lawrence Simon¹²³^ORCID,O’Sullivan Timothy¹²⁵^ORCID

Affiliation:

1. School of Chemistry, University College Cork

2. Analytical and Biological Chemistry Research Facility, University College Cork

3. Synthesis and Solid-State Pharmaceutical Centre, University College Cork

4. Department of Physical Sciences, Cork Institute of Technology

5. School of Pharmacy, University College Cork

Abstract

Efficient S-acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively on the sulfur atom of thiourea is provided by single-crystal X-ray crystallographic analysis.

Funder

Science Foundation Ireland

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Materials Science (miscellaneous),Biomaterials,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610370.pdf

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