Affiliation:
1. Graduate School of Pharmaceutical Sciences, Nagoya University
Abstract
A total synthesis of lycoposerramine-R was accomplished. The synthesis featured a Claisen–Ireland rearrangement to install a two-carbon unit, and a hetero-Diels–Alder reaction to form a cyclic enol ether that reacted with an ethynyl group to construct a cis-hydrindane core containing a quaternary carbon. A 2-pyridone synthesis using 2-(phenylsulfinyl)acetamide was used to complete the synthesis.
Funder
JSPS KAKENHI Grant
Japan Agency for Medical Research and Development
Cited by
4 articles.
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