One-Pot Construction of 3-Phthalimido-1,5-benzodiazepine-2-one Derivatives via in situ Activation of N,N-Phthaloyl-serine-Reference-Cited by-同舟云学术

One-Pot Construction of 3-Phthalimido-1,5-benzodiazepine-2-one Derivatives via in situ Activation of N,N-Phthaloyl-serine

Published:2018-06-07 Issue:12 Volume:29 Page:1639-1643
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Obara Nobuhiro¹,Watanabe Takeshi²,Asakawa Tomohiro²³,Kan Toshiyuki²,Tanaka Takao¹

Affiliation:

1. Zeria Pharmaceutical Co., Ltd

2. School of Pharmaceutical Sciences, University of Shizuoka

3. Tokai University Institute of Innovative Science and Technology

Abstract

The Michael addition of dehydroalanine-activated ester in situ generated from N,N-phthaloyl-serine with o-phenylenediamine followed by cyclization has been established under mild conditions, which afforded 3-phthalimido-1,5-benzodiazepine-2-one derivatives in moderate to good yields.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610026.pdf

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