Affiliation:
1. N. D. Zelinsky Institute of Organic Chemistry
2. Department of Chemistry, M. V. Lomonosov Moscow State University
Abstract
A novel strategy for the synthesis of stereochemically defined 3,4,5-trisubstituted 2-pyrrolidones was developed. The suggested approach involves reductive domino-type recyclization of 3-aminomethyl-substituted isoxazolines as a key stage. The latter are prepared via α-C–H functionalization of readily available isoxazoline-N-oxides.
Cited by
12 articles.
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