Synthesis of Linear α,β-Unsaturated Amides from Isocyanates and Alkenylaluminum Reagents

Abstract

A new approach has been developed for the synthesis of linear α,β-unsaturated amides by the direct coupling of isocyanates with alkenylaluminum reagents. At room temperature, the desired α,β-unsaturated amides were isolated in good to excellent yields with good functional-group tolerance in the absence of any catalyst or additive.