Abstract
AbstractThe ubiquity of carboxylic acids as naturally derived or man-made chemical feedstocks has spurred the development of powerful, decarboxylative C–C bond-forming transformations for organic synthesis. Carboxylic acids benefit not only from extensive commercial availability, but are stable surrogates for organohalides or organometallic reagents in transition-metal-catalysed cross-coupling. Open shell reactivity of carboxylic acids (or derivatives thereof) to furnish carbon-centred radicals is proving transformative for synthetic chemistry, enabling novel and strategy-level C(sp3)–C bond disconnections with exquisite chemoselectivity. This short review will summarise several of the latest advances in this ever-expanding area.1 Introduction2 Improved Decarboxylative Arylations3 sp3–sp3 Cross-Coupling of Carboxylic Acids with Aliphatic Bromides4 sp3–sp3 Cross-Coupling of Carboxylic Acids with Aliphatic Alcohols and Amines5 Doubly Decarboxylative sp3–sp3 Cross-Coupling of Carboxylic Acids6 Decarboxylative C–C Bond Formation from (Hetero)aryl Carboxylic Acids7 Conclusions
Funder
Royal Society
Engineering and Physical Sciences Research Council
University of Bath
UCB Biopharma
AstraZeneca
Janssen
Syngenta
Subject
Organic Chemistry,Catalysis
Cited by
7 articles.
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