Affiliation:
1. College of Health Science, Wuhan Sports University, Wuhan,
China
2. Department of Sports Medicine, Affiliated Hospital, Wuhan Sports
University, Wuhan, China
Abstract
AbstractTo systematically review of randomized controlled trials (RCTs) to compared the
effects of leukocyte-rich and leukocyte-poor platelet-rich plasma in
arthroscopic rotator cuff repair. Two independent reviewers comprehensively
searched PubMed, Embase, and Cochrane library databases according to the
Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Comparison of leukocyte-rich platelet-rich plasma or leukocyte-poor
platelet-rich plasma in rotator cuff repair in a level I RCTs. Methodological
quality assessment was carried out using Cochrane Review Manager 5.3 software.
P<0.05 was considered statistically significant. Nine RCTs with 540
patients were included in this review. Meta-analysis showed that leukocyte-poor
platelet-rich plasma in significantly reduced retear rate in rotator cuff repair
[RR=0.56 95% CI (0.42, 0.75); P<0.05), and in clinical
results, the constant score [MD=3.67, 95% CI (1.62, 5.73);
P=0.0005], UCLA score [MD=1.60, 95% CI (0.79, 2.42);
P=0.0001], ASES score [MD=2.16, 95% CI (0.12, 4.20);
P=0.04] were significantly improved. There was a significant result in
favor of PRP for the Constant score [MD=−1.24, 95% CI
(−1.50, −0.99); P<0.00001], while SST scores were not
significantly different among all groups [MD=0.21, 95% CI
(−0.21, 0.64); P=0.32]. In conclusion, leukocyte-poor
platelet-rich plasma can improved the clinical function and reduced retear rate
in arthroscopic rotator cuff repair. In contrast, the efficacy of leukocyte-rich
platelet-rich plasma was not significantly improved with the exception of VAS
score.
Funder
Hubei Provincial Natural Science Foundation of China
Donghu Scholar Program
of Wuhan Sports University and Research Fund for Young Teachers
of Wuhan Sports University
Young and Middle-Aged
Scientific Research and Innovation Team Project of Wuhan Sports
University
Subject
Orthopedics and Sports Medicine,Physical Therapy, Sports Therapy and Rehabilitation
Cited by
2 articles.
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