Affiliation:
1. College of Biomedical and Pharmaceutical Science, Guangdong University
of Technology, Higher Education Mega Center, Guangzhou, China
2. College of pharmacy, Sun Yet-Sen University, Higher Education Mega
Center, Guangzhou, China
Abstract
Abstract
Background Inhalation preparation involves liquid or solid raw materials
for delivering to lungs as aerosol or vapor. The liquid preparation for
nebulizer is effective for convenient use and patient compliance and it has been
extensively used in the treatment of clinical lung diseases. Clinical staff
often mixes the compound ipratropium bromide with beclomethasone propionate and
budesonide inhaler but reference values of inhalants for clinical use need to be
established for simplifying the operation procedure. The high-performance liquid
chromatography (HPLC) method of compound ipratropium bromide solution,
beclomethasone propionate suspension and budesonide suspension after mixed
atomization was studied.
Methods The specificity, linearity, recovery (accuracy), precision and
stability of compound ipratropium bromide, beclomethasone propionate and
budesonide were tested to verify the developed liquid phase method.
Results The developed liquid phase method had high specificity, linear
R2≥0,999, recovery (accuracy) RSD (relative standard deviation) less
than 2%, precision RSD less than 2,0%, and stability RSD less
than 2,0%.
Conclusion The liquid phase methodology developed in this study can be
used for the determination of compound ipratropium bromide mixed with
beclomethasone propionate and budesonide. The current methodology can also be
used to provide a reference for the determination of its content after mixing,
and further data support for its clinical medication.
Subject
Drug Discovery,General Medicine
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