Affiliation:
1. Department of Ophthalmology, The People’s Hospital of Fenghua,
Ningbo, China
Abstract
AbstractThe aim of the study was to investigate the relationship between
VEGF-460C/T polymorphism and susceptibility to diabetic retinopathy (DR)
in type 2 diabetes mellitus (T2DM) by meta-analysis. A comprehensive search was
conducted across six databases until September 2023 to identify studies
examining the association between VEGF-460C/T polymorphism and
susceptibility to DR. Data process was performed by Stata 15.0 software. Eight
studies were included, involving 1463 patients with DR. In the overall analysis,
the difference was statistically significant only in the homozygous model (CC
vs. TT: OR=1.86, p=0.048). A subgroup analysis of 6 papers with
genotype frequency satisfying HWE in the control group indicated significant
differences among the allele (C vs. T: OR=1.34, p=0.037),
recessive (CC vs. CT+TT: OR=1.96, p=0.022) and
homozygous (CC vs. TT: OR=2.28, p=0.015) models. However, in the
dominant and heterozygous models, the difference was not statistically
significant. The sensitivity of the HWE-based subgroup analysis showed that the
conclusions in other gene models except the heterozygote model were not robust.
This meta-analysis indicated that VEGF-460C/T gene polymorphism is
associated with susceptibility to DR in T2DM. Allele C and genotype CC at the
VEGF-460C/T locus are associated with an increased risk of DR in T2DM.
However, considering that the results are not robust, more trials involving more
rigorous design are needed to verify the findings of this review in the
future.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism
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