Chiron Approach for the Total Synthesis of Brevipolide M-Reference-Cited by-同舟云学术

Chiron Approach for the Total Synthesis of Brevipolide M

Published:2022-01-04 Issue:05 Volume:33 Page:478-482
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Liu Jun¹²^ORCID,Du Yuguo¹²,Liu Yang¹²,Zhao Ziyang¹²,Hu Chao¹,Zhao Chuanfang¹²

Affiliation:

1. State Key Laboratory of Environmental Chemistry and Eco-Toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Science

2. School of Chemical Sciences, University of Chinese Academy of Sciences

Abstract

AbstractAn efficient stereoselective synthesis of brevipolide M was established in 13 linear steps and 17.8% overall yields based on chiron approach. The key steps of our synthesis involved tandem Wittig olefination–tetrahydrofuran cyclization and sequential ring-closing metathesis (RCM)–double-bond migration in one-pot processes.

Funder

Chinese Academy of Sciences

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1730-9857.pdf

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