Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium-Reference-Cited by-同舟云学术

Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium

Published:2017-05-12 Issue:17 Volume:83 Page:1361-1367
ISSN:0032-0943
Container-title:Planta Medica
language:en
Short-container-title:Planta Med

Author:

Du Qizhen¹²,Zhao Yongchun²³,Liu Hongchun⁴,Tang Chunping³,Zhang Minmin⁴,Ke Changqiang³,Ye Yang³⁵

Affiliation:

1. The Key Laboratory for Quality Improvement of Agricultural Products of Zhejiang Province, The College of Agricultural and Food Sciences, Zhejiang A & F University, Linan, Peopleʼs Republic of China

2. Institute of Food Chemistry, Zhejiang Gongshang University, Hangzhou, Zhejiang, Peopleʼs Republic of China

3. State Key Laboratory of Drug Research and Department of Natural Product Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, Peopleʼs Republic of China

4. Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, Peopleʼs Republic of China

5. School of Life Science and Technology, ShanghaiTech University, Shanghai, Peopleʼs Republic of China

Abstract

AbstractNine new and eleven known phorbol esters were isolated from an acetone extract of the seeds of Croton tiglium. Their structures were determined by extensive analysis of spectroscopic data. Eleven of these compounds were evaluated for their inhibition activity on human tumor cell lines HL-60 and lung carcinoma A549. 12-O-Tiglylphorbol-13-acetate (11), 12-O-(2-methyl)-butyrylphorbol-13-aetate (12), and 12-O-tiglylphorbol-13-isobutyrate (13) exhibited strong inhibition activity against both HL-60 and A549 cell lines with IC50 values ≤ 0.02 and ≤ 0.1 µg/mL, respectively. Compound 18 showed strong inhibition activity against the HL-60 cell line with an IC50 value of 0.02 µg/mL.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-110227.pdf

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